@charset "UTF-8";html{box-sizing:border-box;font-size:16px}*,*:before,*:after{box-sizing:inherit}body,h1,h2,h3,h4,h5,h6,p,ol,ul{margin:0;padding:0;font-weight:400}img{max-width:100%;height:auto}button{border:none;box-shadow:none}.isi{padding:32px 0 20px;font-family:Arial,Open Sans,sans-serif;box-shadow:none;background-color:#fff;scroll-margin-top:120px}@media (max-width: 1024px){.isi{scroll-margin-top:160px}}.isi a{cursor:pointer;text-decoration:underline}.isi a span{text-decoration:underline}.isi .isi__up,.isi .isi__down{display:none}.isi.isi__fixed{position:fixed;top:calc(100dvh - 128px);width:100%;left:0;transition:top .4s;z-index:5000;border-top:1px solid #00a3ad}@media (max-width: 768px){.isi.isi__fixed{left:0;transition:0;-webkit-transform:translate3d(0,0,0)}}.isi.isi__fixed.isi__fixed--not-top{display:-webkit-box;-webkit-line-clamp:3;-webkit-box-orient:vertical;overflow:hidden;padding-bottom:0;padding-top:18px}@media (max-width: 1024px){.isi.isi__fixed.isi__fixed--not-top{overflow:visible;display:block}}.isi.isi__fixed.isi__fixed--not-top p{display:inline}@media (max-width: 1024px){.isi.isi__fixed.isi__fixed--not-top p{display:block;margin-bottom:0}}.isi.isi__fixed .isi__up{display:block;width:15px;height:15px;max-width:none}.isi.isi__fixed .isi__down{display:none;width:15px;height:15px;max-width:none}.isi.top{z-index:9999;padding-left:0;top:95px;height:calc(100dvh - 130px);overflow-y:scroll;-webkit-overflow-scrolling:touch}.isi.top::-webkit-scrollbar{width:5px;position:relative}.isi.top::-webkit-scrollbar-track{box-shadow:inset 0 0 6px #0000004d}.isi.top::-webkit-scrollbar-thumb{background-color:#a9a9a9;outline:1px solid slategrey}.isi.top .isi__arrow,.isi.top .isi__up{display:none}.isi.top .isi__down{display:block}@media (max-width: 768px){.isi.top{padding-bottom:190px;top:204px}}@media (min-width: 768px) and (max-width: 1090px){.isi.top{top:204px}}.isi__container.container{display:flex;justify-content:space-between;padding-top:34px;padding-bottom:82px;position:relative;transform:translateZ(0)}@media (max-width: 1024px){.isi__container.container{display:block}}.isi__control{position:absolute;top:-8px;right:80px;height:20px;width:20px;display:flex;align-items:center;justify-content:center;cursor:pointer}.isi__control .isi__up{display:none}@media (max-width: 1224px){.isi__control{right:40px}}@media (max-width: 768px){.isi__control{right:20px}}.isi__heading{font-size:18px;line-height:20px;color:#00a3ad;font-weight:700;text-transform:uppercase;margin-bottom:12px}.isi__right{flex:1}.isi__left{position:relative;flex-basis:306px}@media (max-width: 1024px){.isi__left{width:auto;flex:0 0 0 1;margin:0 0 30px}}#isiOverlay{width:100%;height:200px;position:fixed;z-index:4000;bottom:-100px;background-color:#fff}#main-nav{max-width:1300px;width:100%}#main-nav ul{display:flex;flex-direction:row;justify-content:space-around}.header .header-indication{background-color:#eef0f0;padding:14px 0 8px;max-height:500px;opacity:1;overflow:hidden;transition:max-height .3s ease-in-out,opacity .5s ease-in-out,padding .3s ease-in-out}.header .header-indication.hidden{max-height:0;opacity:0;padding:0}.header .indication-block-button{margin-bottom:auto;width:20px;height:auto;margin-left:15px;cursor:pointer}@media (max-width: 1024px){.header .indication-block-button{width:15px}}.header .header-content{padding:8px 0 10px}.header .header-content .container{align-items:flex-end;justify-content:space-between}@media (max-width: 768px){.header .header-content .container{flex-wrap:wrap}}.header .header-content .header-logo{width:123px;height:auto}@media (max-width: 768px){.header .header-content .header-logo{order:1}}.header .header-content .header-menu{margin-left:auto}@media (max-width: 768px){.header .header-content .header-menu{order:3;width:100%;margin-top:14px;display:flex;justify-content:space-evenly}}.header .header-content .header-menu a{cursor:pointer;text-decoration:underline}@media (max-width: 768px){.header .header-content .header-menu a{margin-bottom:8px;display:inline-block}}.header .header-content .header-menu a:first-child{margin-right:26px}@media (max-width: 768px){.header .header-content .header-menu a:first-child{margin-right:5px}}.header .indication-button{margin-left:37px;background-color:transparent;cursor:pointer;padding:0}@media (max-width: 768px){.header .indication-button{order:2}}.header .indication-button img{width:14px;height:auto}.header .indication-button .open-indication-button{display:none}.header .indication-button.active .open-indication-button{display:inline}.header .indication-button.active .close-indication-button{display:none}.interstitial{width:100vw;height:100vh;position:fixed;z-index:9999;top:0;left:0;display:none;align-items:center;justify-content:center;background-color:#00000073}.interstitial .interstitial__close{position:absolute;top:22px;right:20px;width:20px;cursor:pointer}.interstitial .interstitial__content{width:640px;position:relative;padding:58px 20px 20px 25px;border-radius:4px;background-color:#fff;color:#000}@media (max-width: 1024px){.interstitial .interstitial__content{width:calc(100vw - 40px);height:auto;padding:58px 18px 20px 25px;transform:translateY(0)}.interstitial .interstitial__content .interstitial__buttons{width:100%;text-align:left}}.interstitial .interstitial__content h4{margin-bottom:28px;font-weight:700;font-size:24px;color:#0a48cc;line-height:28px}.interstitial .interstitial__content p{margin-bottom:16px;font-size:18px;line-height:26px}.interstitial .interstitial__content button{margin-top:10px;margin-right:18px;min-width:88px;padding:9px;border:none;border-radius:5px;background-color:#00a3ad;box-shadow:none;letter-spacing:.5px;font-weight:700;font-size:20px;color:#fff;cursor:pointer}@media (max-width: 768px){.interstitial .interstitial__content button{margin-top:24px}}.footer .footer-top{display:flex;align-items:flex-end;margin-bottom:40px}@media (max-width: 768px){.footer .footer-top{display:block}}.footer .footer-logo{max-width:144px;margin-right:40px}@media (max-width: 768px){.footer .footer-logo{margin-bottom:20px}}.footer .footer-bottom{padding-bottom:60px}.kol.container{position:relative;display:block;padding:35px 38px 40px;color:#fff;background:#950050;background:linear-gradient(-90deg,rgb(218,71,51) 0%,rgb(148,0,79) 30% rgb(148,0,79) 70% rgb(163,0,63) 100%)}@media (max-width: 1024px){.kol.container{display:flex;flex-wrap:wrap;padding:50px 24px 60px}}.kol.container .kol__icon{width:150px;height:180px;overflow:hidden;position:relative;z-index:10;flex:inherit;margin-left:40px}@media (max-width: 768px){.kol.container .kol__icon{margin-left:0}}.kol.container .kol__icon img{height:100%;width:100%;-o-object-fit:cover;object-fit:cover;-o-object-position:top center;object-position:top center}@media (max-width: 1024px){.kol.container .kol__icon img{width:auto}}.kol.container .kol__text{position:relative;padding-top:14px;padding-right:18px}@media (max-width: 1024px){.kol.container .kol__text{display:flex;flex-direction:column;width:100%;padding-top:18px}}@media (max-width: 768px){.kol.container .kol__text{padding:0 18px}}.kol.container .kol__text h2.kol__pov{position:relative;margin-bottom:55px}@media (max-width: 1024px){.kol.container .kol__text h2.kol__pov{order:2;font-size:22px;line-height:24px;margin-bottom:0;margin-left:14px}}.kol.container .kol__text h2.kol__pov:before,.kol.container .kol__text h2.kol__pov:after{position:absolute;top:-6px;color:#f47b20;font-weight:700;font-size:40px;line-height:1em}@media (max-width: 1024px){.kol.container .kol__text h2.kol__pov:before,.kol.container .kol__text h2.kol__pov:after{font-size:30px;line-height:32px}}.kol.container .kol__text h2.kol__pov:before{left:-20px;content:"“"}@media (max-width: 1024px){.kol.container .kol__text h2.kol__pov:before{left:-14px}}.kol.container .kol__text h2.kol__pov:after{padding-left:6px;position:relative;line-height:0;content:"”";top:2px;left:-5px}@media (max-width: 1024px){.kol.container .kol__text .kol_info{order:1;margin-bottom:40px}}.kol.container .kol__text p{margin-bottom:0}.kol.container .kol__text p.featured{margin-bottom:4px}body{font-family:Arial,Open Sans,sans-serif;color:#575959;scroll-behavior:smooth;overflow:scroll;height:100%}body.fixed{height:100vh;width:100%;position:fixed}body.modal-fixed{overflow:hidden}*{box-sizing:border-box;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}img{width:100%;height:auto}sup,sub{position:relative;top:.1em;font-size:.6em;line-height:0}sub{top:.4em}.no-break{white-space:nowrap}section{z-index:1}#isiTarget{position:relative;width:100%;height:0px}.main-wrap{z-index:1}.with-hanger{position:relative}.with-hanger .hanger{position:absolute;left:-5px}.with-hanger .double-hanger{position:absolute;left:-10px}.with-hanger sup.hanger{top:3px}.container{position:relative;width:100%;max-width:1300px;margin:0 auto;padding:0 80px}@media (max-width: 1024px){.container{padding:0 20px}}.container.gradient{background:linear-gradient(90deg,#0a48cc,#26cfb3)}.container.flex,.desktop-flex{display:flex}@media (max-width: 1024px){.desktop-flex{display:block}}.primary-color{color:#0a48cc}.secondary-color{color:#00a3ad}.font-16{font-size:16px}.h1-heading{font:400 37px/1.14 Arial,Open Sans,sans-serif;color:#fff}@media (max-width: 768px){.h1-heading{font:400 30px/1.13 Arial,Open Sans,sans-serif}}.h2-heading{font:400 24px/1.2 Arial,Open Sans,sans-serif;color:#fff}@media (max-width: 768px){.h2-heading{font:400 21px/1.2 Arial,Open Sans,sans-serif}}.h2-subheading{font:400 20px/1.14 Arial,Open Sans,sans-serif;color:#fff}@media (max-width: 768px){.h2-subheading{font:400 20px/1.2 Arial,Open Sans,sans-serif}}.large-text{font:400 20px/24px Arial,Open Sans,sans-serif;color:#707070}.regular-text{font:400 18px/1.2 Arial,Open Sans,sans-serif;color:#000}@media (max-width: 1024px){.regular-text{line-height:1.17}}.regular-text.lh-static{line-height:1.2}.regular-text.primary-color{color:#0a48cc}.regular-text.secondary-color{color:#00a3ad}.small-regular-text{font:400 14px/1.07 Arial,Open Sans,sans-serif;color:#000}.small-regular-text.primary-color{color:#0a48cc}.small-regular-text.secondary-color{color:#00a3ad}.medium-regular-text{font:400 16px/20px Arial,Open Sans,sans-serif;color:#000}.medium-regular-text.primary-color{color:#0a48cc}.medium-regular-text.secondary-color{color:#00a3ad}.medium-regular-text.violet-color{color:#7d55c6}.small-text{font:400 12px/1.2 Arial,Open Sans,sans-serif;color:#000}.small-text.large{line-height:1.3;margin-bottom:3px}.small-text.grey-color,.small-text a{color:#999}.small-text.mb-18{margin-bottom:18px}ul.green-marker{margin-block-start:0;padding-inline-start:18px}ul.green-marker li::marker{color:#00a3ad}ul.black-marker{margin-block-start:0;padding-inline-start:18px}ul.black-marker li::marker{color:#000}ul ul{padding-inline-start:28px!important;list-style:disc}.two-columns-block{display:flex}@media (max-width: 768px){.two-columns-block{display:block}}.two-columns-block .col{width:50%}@media (max-width: 768px){.two-columns-block .col{width:100%}}@media (min-width: 64em){.two-column{display:flex;justify-content:space-between}}.two-column.humoral-response{gap:16px}.two-column.humoral-response .cell.left-cell{margin-bottom:18px}@media (min-width: 64em){.two-column.humoral-response .cell.left-cell{width:440px;flex-basis:440px;margin:0}}.two-column.humoral-response .cell.left-cell IMG{width:inherit}.two-column.humoral-response .cell.right-cell{flex:1;display:flex;flex-direction:column;justify-content:flex-end}.two-column.primary-endpoints .cell{flex-basis:50%}.two-column.primary-endpoints .cell.left-cell{margin-bottom:18px}@media (min-width: 64em){.two-column.primary-endpoints .cell.left-cell{margin:0}}.two-column.time-to-relapse{gap:20px}.two-column.time-to-relapse .cell.left-cell{margin-bottom:18px;flex-basis:554px}@media (min-width: 64em){.two-column.time-to-relapse .cell.left-cell{margin:0}.two-column.time-to-relapse .cell.right-cell{flex:1;padding-top:30px}}.two-column.careful-monitoring .cell{display:flex;flex-direction:column;align-items:center;text-align:center;flex-basis:50%;padding:0 20px;margin-bottom:18px}@media (min-width: 64em){.two-column.careful-monitoring .cell{margin-bottom:40px}}.two-column.careful-monitoring:last-child .cell{margin:0}.large-numbered-list .item{display:flex;gap:8px}.large-numbered-list .item .number{width:24px;height:24px;border-radius:50%;background-color:#41e6ba;display:flex;align-items:center;justify-content:flex-end;font-size:18px;line-height:1em;font-weight:700;color:#000;padding-right:2px}.large-numbered-list .item .text{flex:1}.violet-gradient-box{width:100%;padding:20px;display:flex;flex-direction:column;align-items:center;gap:16px;background:linear-gradient(90deg,#eae4f6,#fff)}@media (min-width: 64em){.violet-gradient-box{flex-direction:row;align-items:flex-end}}.green-gradient-item{width:100%;padding:8px 50px 8px 25px;display:flex;flex-direction:column;align-items:flex-start;gap:16px;background:linear-gradient(90deg,#fff,#29cfb4);margin-bottom:10px}@media (min-width: 64em){.green-gradient-item{padding:8px 50px 8px 12px;align-items:center}}.gap-16{gap:16px}.custom-list-type-1{list-style:none}.custom-list-type-1 li{position:relative;padding-left:32px}.custom-list-type-1 li:before{position:absolute;left:0;top:3px;width:25px;height:15px;content:"";background:url(/build/assets/arrow-marker-Bf1hUl4H.svg) no-repeat center/cover}.custom-list-type-1 li ul{list-style:none;margin-top:8px}.custom-list-type-1 li ul li{position:relative;padding-left:18px}.custom-list-type-1 li ul li:before{position:absolute;left:0;top:1px;content:"–";background:none;font-weight:600}.mobile-max-width-670{max-width:670px}@media (min-width: 64em){.mobile-max-width-670{max-width:100%}}.arrow-flex{display:flex;align-items:flex-start;gap:10px}@media (min-width: 64em){.arrow-flex{align-items:center}}.labeled-block{display:flex}@media (max-width: 768px){.labeled-block{display:block;margin-bottom:14px}}.labeled-block .labeled-block-icon{min-width:84px;max-width:84px;margin-right:10px}@media (max-width: 768px){.labeled-block .labeled-block-icon{margin:0 auto 14px;max-width:100px;min-width:100px}}.margin-auto{margin-left:auto;margin-right:auto;display:block}.mb-8{margin-bottom:8px}.mb-18{margin-bottom:18px}.mb-20{margin-bottom:20px}.mb-33{margin-bottom:33px}.mt-22{margin-top:22px}.min-340px{min-width:340px}.max-505px{max-width:505px}.max-578px{max-width:578px}.cta-button{background-color:#00a3ad;padding:22px 25px 18px;border-radius:8px;color:#fff;cursor:pointer}@media (max-width: 1024px){.cta-button{width:100%}}@media (max-width: 768px){.cta-button{padding:22px 20px 18px}}.cta-button-link{cursor:pointer;display:block;text-decoration:none;text-align:center;background-color:#00a3ad;padding:22px 15px 18px;border-radius:8px;color:#fff}.inline-block{display:inline-block}@media (max-width: 1024px){.desktop-only{display:none!important}}.desktop-not-tablet{display:block}@media (max-width: 1024px){.desktop-not-tablet{display:none!important}}@media (min-width: 768px) and (max-width: 1090px){.desktop-not-tablet{display:none!important}}@media (min-width: 1024px){.mobile-only{display:none!important}}.desktop-tablet{display:block}@media (max-width: 768px){.desktop-tablet{display:none!important}}.tablet-only{display:none}@media (max-width: 1024px){.tablet-only{display:none}}@media (max-width: 1300px){.tablet-only{display:block}}.tablet-below{display:none!important}@media (min-width: 768px) and (max-width: 1090px){.tablet-below{display:block!important}}@media (max-width: 1024px){.tablet-below{display:block!important}}.above-tablet{display:block}@media (min-width: 768px) and (max-width: 1090px){.above-tablet{display:none}}@media (max-width: 1024px){.above-tablet{display:none}}.below-tablet{display:none!important}@media (max-width: 768px){.below-tablet{display:block!important}}@media (max-width: 1024px){.mobile-center{display:block;margin-left:auto!important;margin-right:auto!important}}@media (min-width: 500px) and (max-width: 768px){.high-mobile-center{display:block;margin-left:auto!important;margin-right:auto!important;text-align:center}}.overrr{display:none}@media (min-width: 1300px){.overrr{display:block}}.left{text-align:left}.center{text-align:center}.right{text-align:right}.regular{font-weight:400}.semiBold{font-weight:600}.button-corners{border-radius:50px;overflow:hidden;cursor:pointer;border:none;background-color:transparent;min-height:50px;padding:0}@media (max-width: 1024px){.button-corners{border-radius:48px}}.button-corners--alt{border-radius:50px;overflow:hidden;cursor:pointer;border:none;background-color:transparent}@media (max-width: 1024px){.button-corners--alt{border-radius:60px}}.asterisk{margin-left:6px;position:relative}.asterisk:before{content:"*";position:absolute;left:-4px;font-size:.8em}.dagger{position:relative;margin-left:6px}.dagger:before{content:"†";position:absolute;vertical-align:baseline;left:-5px;top:-2px;font-size:.75em}.doubledagger{position:relative;margin-left:6px}.doubledagger:before{content:"‡";position:absolute;vertical-align:baseline;left:-5px;top:-2px;font-size:.75em}.swirl{position:relative}.swirl:before{content:"§";position:absolute;left:-5px;vertical-align:baseline;top:-.3em;font-size:.6em}.middle-wrapper{position:relative;z-index:1}.show-content .content{display:none}.capital{text-transform:uppercase}.full-width-image{width:100%}.error h2.heading{font-size:36px;font-weight:700;font-color:#0a48cc;margin-bottom:15px;text-decoration:underline}.error .error__header{width:400px;margin:6px 0 40px}.error .header-indication,.error .indication-button,.error .header .header-content div.header-menu{display:none}.hero{background:linear-gradient(90deg,#0a48cc,#0a48cc 50%,#26cfb3 50%,#26cfb3)}.hero .container{background:linear-gradient(90deg,#0a48cc,#26cfb3);padding-top:33px;padding-bottom:33px;position:relative;overflow:hidden}@media (max-width: 1024px){.hero .container{padding-top:23px;padding-bottom:23px}}.hero .container .h2-heading,.hero .container .h1-heading{margin-bottom:8px;z-index:2;position:relative;padding-right:140px}@media (max-width: 1024px){.hero .container .h2-heading,.hero .container .h1-heading{padding-right:0}}.hero .container .h2-subheading{z-index:2}.hero .container .hero-bg-image{z-index:1;position:absolute;right:80px;top:20px;height:auto;width:195px}@media (max-width: 1024px){.hero .container .hero-bg-image{display:none}}.quiz{padding-top:20px}.quiz.min-height-60vh{min-height:60vh}.quiz-content-wrapper{justify-content:space-between;gap:20px}.quiz-content-wrapper .quiz-content-wrapper-left{max-width:760px}@media (max-width: 1024px){.quiz-content-wrapper .quiz-content-wrapper-left{max-width:none}}.quiz__question-container{background-color:#eff0f2;border-radius:8px;padding:26px 30px 35px}@media (max-width: 1024px){.quiz__question-container{padding:26px 23px 24px}}.quiz__question-container input[type=radio]{display:none}.quiz__question-container .label-text{display:flex;gap:7px}.quiz__question-container label{display:flex;align-items:center;cursor:pointer;position:relative;padding-left:26px;-webkit-user-select:none;-moz-user-select:none;user-select:none;margin-top:1px}.quiz__question-container label .checkmark{position:absolute;left:0;top:2px;height:16px;width:16px;background-color:#fff;border:1px solid black;border-radius:50%;transition:background-color .3s,border-color .3s}.quiz__question-container .checkmark:after{content:"";position:absolute;display:none;top:50%;left:50%;transform:translate(-50%,-50%);height:10px;width:10px;border-radius:50%;background:#000}.quiz__question-container input[type=radio]:checked+.checkmark:after{display:block}.quiz__answer-container,.quiz__next-button{display:none}.answer-content__answer{border-radius:8px;background-color:#0a48cc;padding:20px 32px;width:100%;color:#fff;margin:20px 0;display:flex;align-items:center;line-height:1}@media (max-width: 1024px){.answer-content__answer{padding:20px 25px}}.answer-content__answer .answer-content__answer--value{font-size:40px;line-height:1.07;margin-left:20px}.references{padding-bottom:60px}.references p.small{line-height:16px}.show-on-answer{display:none}